Minimalist active-site redesign: teaching old enzymes new tricks.

Teaching Old Dogs New Tricks Implementing Organizational Learning in an Asian National Police Force

Teaching an Old Course New Tricks: A Portable Courseware Language Based on XML

Yeast biotechnology: teaching the old dog new tricks

Yeasts are regarded as the first microorganisms used by humans to process food and alcoholic beverages. The technology developed out of these ancient processes has been the basis for modern industrial biotechnology. Yeast biotechnology has gained great interest again in the last decades. Joining the potentials of genomics, metabolic engineering, systems and synthetic biology enables the product...

Two New Concepts in Video Podcasts - Minimalist Slides and Modular Teaching Mini-videos

Nowadays the main learning resources are traditional board, slides and video podcasts. Each of them with their own strengths and weaknesses. Analysing the advantages and disadvantages of the traditional board and slides we have created, with the advantages of both resources, a new concept that we have named “minimalist slides”. Using the minimalist slides we have introduced a new type of video ...

Computational redesign of a mononuclear zinc metalloenzyme for organophosphate hydrolysis.

The ability to redesign enzymes to catalyze noncognate chemical transformations would have wide-ranging applications. We developed a computational method for repurposing the reactivity of metalloenzyme active site functional groups to catalyze new reactions. Using this method, we engineered a zinc-containing mouse adenosine deaminase to catalyze the hydrolysis of a model organophosphate with a ...